Cyclic voltammetric study of biologically active metal ions with norfloxacin

The interaction of biologically active metal ions:Co(II), Cr(III), Fe(III), Mn(II) and Cu(II) with Norfloxacin (NRF) has been studied using cyclic vol tammetric technique, in the potential range +1.5 to -1.0V with DMF and NaCl O4 as supporting medium and platinum as working electrode. The voltammetric pattern shows characteristic peaks with NRF, however, the peaks of the fre e metal ions are influenced by the presence of NRF indicating complexation with the metal ions. The results show that NRF forms complexes with metal i ons (M-NRF) in 1:2 ratio. The values of stability constant (K-C) and thermo dynamic parameters Delta G degrees, Delta H degrees and Delta S degrees for complex formation are evaluated. These findings reveal the possible use of various metal ions for analytical and chemotherapeutic investigations with NRF.