Review on the chemical constituents of medicinal plants and bioactive natural products - Part IX - Natural taxols

Authors
Das, B Kashinatham, A Anjani, G
Citation
B. Das et al., Review on the chemical constituents of medicinal plants and bioactive natural products - Part IX - Natural taxols, I J CHEM B, 38(9), 1999, pp. 1018-1024
Citations number
136
Categorie Soggetti
Organic Chemistry/Polymer Science
Journal title
INDIAN JOURNAL OF CHEMISTRY SECTION B-ORGANIC CHEMISTRY INCLUDING MEDICINAL CHEMISTRY
ISSN journal
03764699 → ACNP
Volume
38
Issue
9
Year of publication
1999
Pages
1018 - 1024
Database
ISI
SICI code
0376-4699(199909)38:9<1018:ROTCCO>2.0.ZU;2-9
Abstract
Taxols, the N-acyl(N-alkyl)-phenylisoserine esters of baccatin III-type tax oids, have been reported from different yew plants (Taxus species). The mos t important compound is taxol (taxol A, taxol(R) paclitaxel) which is a lea d anticancer agent in recent years. Overall, twenty-eight natural taxols ar e known to date. The literature concerning the chemistry and bioactivity of these compounds has been briefly reviewed.