Synthesis and antimicrobial activity of 1,3,5-triaryl-10-benzyl-1,2,3,4,6,7,8,9-octahydro-8,8-dimethyl-4,6-dioxo-2-thioxo-5H,10H-pyrimido[4,5-b]quinolines

Authors
Ahluwalia, VK Sahay, R Das, U
Citation
Vk. Ahluwalia et al., Synthesis and antimicrobial activity of 1,3,5-triaryl-10-benzyl-1,2,3,4,6,7,8,9-octahydro-8,8-dimethyl-4,6-dioxo-2-thioxo-5H,10H-pyrimido[4,5-b]quinolines, I J CHEM B, 38(9), 1999, pp. 1136-1138
Citations number
12
Categorie Soggetti
Organic Chemistry/Polymer Science
Journal title
INDIAN JOURNAL OF CHEMISTRY SECTION B-ORGANIC CHEMISTRY INCLUDING MEDICINAL CHEMISTRY
ISSN journal
03764699 → ACNP
Volume
38
Issue
9
Year of publication
1999
Pages
1136 - 1138
Database
ISI
SICI code
0376-4699(199909)38:9<1136:SAAAO1>2.0.ZU;2-G
Abstract
A convenient one pot synthesis of some pyrimido[4,5-b]quinoline derivatives 2a-g and 3a-g has been reported by the condensation of 5,5-dimethyl-3-benz ylamino-2-cyclohexen-1-one with appropriate arylaldehydes and 1,3-diaryl-2- thiobarbituric acids in methanol and screened for their antimicrobial activ ity. Some of the compounds show significant activity.