A convenient one-pot synthesis of 2-substituted-4,6-diaryl pyrimidines

Authors
Sharma, P Hussain, KF Sukhwal, S Kothari, S Singhal, M Verma, BL
Citation
P. Sharma et al., A convenient one-pot synthesis of 2-substituted-4,6-diaryl pyrimidines, I J CHEM B, 38(8), 1999, pp. 966-968
Citations number
14
Categorie Soggetti
Organic Chemistry/Polymer Science
Journal title
INDIAN JOURNAL OF CHEMISTRY SECTION B-ORGANIC CHEMISTRY INCLUDING MEDICINAL CHEMISTRY
ISSN journal
03764699 → ACNP
Volume
38
Issue
8
Year of publication
1999
Pages
966 - 968
Database
ISI
SICI code
0376-4699(199908)38:8<966:ACOSO2>2.0.ZU;2-H
Abstract
variously substituted chalcones 1 on treatment with S-benzyl isothiouronium chloride in the presence of ethanol-morpholine/ piperidine/ pyrrolidine or DMF give 4,6-diaryl-2-(4-morpholinyl/1-piperidinyl/1-pyrrolidinyl) pyrimid ines 4a-p and 2-benzyl-thiopyrimidines 3 a-e in a facile one step conversio n. An alternate synthesis of 4g, h, j, k is also described.