Studies on anti-inflammatory drugs of 2-arylpropanoic acids: Part IX - A practical synthesis of ketoprofen by 1,2-aryl rearrangement

Authors
Chen, FN Liu, JD Sho, LY Yan, QJ
Citation
Fn. Chen et al., Studies on anti-inflammatory drugs of 2-arylpropanoic acids: Part IX - A practical synthesis of ketoprofen by 1,2-aryl rearrangement, I J CHEM B, 38(8), 1999, pp. 989-992
Citations number
10
Categorie Soggetti
Organic Chemistry/Polymer Science
Journal title
INDIAN JOURNAL OF CHEMISTRY SECTION B-ORGANIC CHEMISTRY INCLUDING MEDICINAL CHEMISTRY
ISSN journal
03764699 → ACNP
Volume
38
Issue
8
Year of publication
1999
Pages
989 - 992
Database
ISI
SICI code
0376-4699(199908)38:8<989:SOADO2>2.0.ZU;2-D
Abstract
An efficient synthesis of ketoprofen via chloration, Friedel-Crafts acylati on, reduction, coupling, ketalization, rearrangement, hydrolysis and oxidat ion from commercially available bromo-benzoic acid in overall yield of abou t 60% has been described.