Solid-phase synthesis and photophysical properties of DNA labeled at the nucleobase with Ru(bpy)(2)(4-m-4 '-pa-bpy)(2+)

Authors
Khan, SI Beilstein, AE Tierney, MT Sykora, M Grinstaff, MW
Citation
Si. Khan et al., Solid-phase synthesis and photophysical properties of DNA labeled at the nucleobase with Ru(bpy)(2)(4-m-4 '-pa-bpy)(2+), INORG CHEM, 38(26), 1999, pp. 5999-6002
Citations number
47
Categorie Soggetti
Inorganic & Nuclear Chemistry
Journal title
INORGANIC CHEMISTRY
ISSN journal
00201669 → ACNP
Volume
38
Issue
26
Year of publication
1999
Pages
5999 - 6002
Database
ISI
SICI code
0020-1669(199912)38:26<5999:SSAPPO>2.0.ZU;2-7
Abstract
A facile procedure for incorporating a Ru(diimine)(3)(2+) complex at the nu cleobase in an oligonucleotide is reported that combines the advantages of Pd(0) cross-coupling and solid-phase DNA chemistries. These ruthenium-modif ied oligonucleotides form stable duplexes, and the favorable photophysical properties associated with the Ru(diimine)(3)(2+) complex are retained afte r site-specific covalent attachment.