Nh. Carbonetti et al., Overexpression of the RNA polymerase alpha subunit reduces transcription of Bvg-activated virulence genes in Bordetella pertussis, J BACT, 182(2), 2000, pp. 529-531
Overexpression of the RNA polymerase alpha subunit in Bordetella pertussis
reduces expression of the virulence factor pel tussis toxin, Here me show t
hat this reduction is at the level of transcription, is reversed by overexp
ression of the transcriptional activator BvgA, and is dependent on the C-te
rminal domain of alpha.