Commentary: Future considerations for models of human neurobehavioral function

Citation
Df. Dinges et P. Achermann, Commentary: Future considerations for models of human neurobehavioral function, J BIOL RHYT, 14(6), 1999, pp. 598-601
Citations number
9
Categorie Soggetti
Physiology
Journal title
JOURNAL OF BIOLOGICAL RHYTHMS
ISSN journal
07487304 → ACNP
Volume
14
Issue
6
Year of publication
1999
Pages
598 - 601
Database
ISI
SICI code
0748-7304(199912)14:6<598:CFCFMO>2.0.ZU;2-Q
Abstract
Modeling human neurobehavioral functions has the goal of identifying work-r est schedules that are safer and more productive. The models of Folkard et al. and of Jewett and Kronauer illustrate excellent progress toward this go al. Examination of these models reveals four additional areas that need to be addressed to facilitate continued development of accurate models of neur obehavioral-functions. (1) The choice of neurobehavioral metrics may have a significant influence on model development. The lack of correlation among different neurobehavioral measures may make comparisons of models difficult . Many neurobehavioral measures are confounded by secondary and random erro r variance that can lead to model distortion. Although different models may ultimately be required for different neurobehavioral functions, measures t hat have been extensively validated to be sensitive to circadian variation and sleep loss should take priority in model development. (2) Because error variance in neurobehavioral outcomes can be substantial in uncontrolled en vironments, model validation should proceed from controlled laboratory prot ocols to real-world scenarios. Once validated, the ability of a model to pr edict field data can be tested. (3) While neurobehavioral models have been developed to predict behavior over time (i.e., within-subjects), to be usef ul in the real world, models will also ultimately have to provide estimates of between-subject variation in vulnerability to neurobehavioral dysfuncti on during night work or sleep loss (e.g., younger versus older workers). (4 ) Finally, to be theoretically accurate and practically useful, models of h uman neurobehavioral functions should be able to predict both cumulative ef fects (i.e., across days or weeks) and the influence of countermeasures (e. g., light, naps, caffeine).