Enantiomer separation of alpha-ionone using gas chromatography with cyclodextrin derivatives as chiral stationary phases

The gas chromatographic enantiomer separation of alpha-ionone was studied w ith three different chiral stationary phases using as chiral selectors: (1) heptakis(2,3,6-tri-O-methyl)-beta-cyclodextrin dissolved in polysiloxane P S-086, (2) octakis(2,6-di-O-pentyl-3-O-trifluoroacetyl)-gamma-cyclodextrin and (3) octakis(2,6-di-O-pentyl-3-O-butanoyl)-gamma-cyclodextrin, both diss olved in polysiloxane SE-54. The influence of the concentration of the chir al selector in the polysiloxane, coated on Chromosorb P AW-DMCS 80-100 mesh , is described and discussed, as well as the effect of Chromosorb loading. The feasibility of the preparative gas chromatographic separation of the en antiomers of alpha-ionone is considered; in order to provide a term of comp arison, the estimated performances are compared with those achieved in the separation of the enantiomers of the inhalation anaesthetic enflurane. (C) 1999 Elsevier Science B.V. All rights reserved.