A novel method for assessing assisted female fertility: Bioelectric impedance.

Citation
M. Jinno et al., A novel method for assessing assisted female fertility: Bioelectric impedance., J CLIN END, 85(1), 2000, pp. 471-474
Citations number
25
Categorie Soggetti
Endocrynology, Metabolism & Nutrition","Endocrinology, Nutrition & Metabolism
Journal title
JOURNAL OF CLINICAL ENDOCRINOLOGY AND METABOLISM
ISSN journal
0021972X → ACNP
Volume
85
Issue
1
Year of publication
2000
Pages
471 - 474
Database
ISI
SICI code
0021-972X(200001)85:1<471:ANMFAA>2.0.ZU;2-#
Abstract
Early detection of declining female fertility is important for effective pr evention and treatment of infertility. Age, serum concentration of FSH in t he early follicular phase (basal FSH), and the clomiphene citrate (CC) chal lenge test correlate only with large declines in fertility. We serendipitou sly discovered that by a novel mechanism bioelectric impedance (BEI) sensit ively reflects early fertility decrements. BEI was measured between the rig ht and left arms by the tetrapolar method before and during ovarian stimula tion for in vitro fertilization (IVF). In a stepwise multiple logistic regr ession analysis of five factors (BEI on luteal day 4 prior to the IVF cycle [BEI-L4], age, basal FSH, body height, and body mass index), BEI-IA alone was a significant predictor (P< 0.05) of achievement of pregnancy by IVF in 148 women (74 pregnant and 74 nonpregnant). BEI showed a nadir on the day of administration of hCG in the pregnant but not the nonpregnant group. Ser um concentrations of VEGF during ovarian stimulation were significantly hig her in the pregnant group, but not those of 17 beta-estradiol and progester one. The CC challenge test revealed no significant difference between 11 pr egnant and 15 nonpregnant women. The clinical usefulness of BEI was evaluat ed in 272 consecutive IVF cycles. Rate of pregnancy was significantly highe r (P<0.01) in IVF cycles with BEI-L4 greater than or equal to 600 Omega tha n <600 Omega (44% and 26% in 149 and 123 cycles, respectively). When BEI-IA was greater than or equal to 600 Omega, pregnancy rates were constantly hi gh irrespective of age and basal FSH. In prediction of nonpregnancy, sensit ivity of BEI-IA (0.52) was significantly (P<0.05) higher than those of age and basal FSH (0.39 and 0.046, respectively). BEI, which is easy, noninvasi ve, and inexpensive, predicts female fertility more sensitively than age an d basal FSH, probably reflecting angiogenic capacity of reproductive organs .