Novel synthetic methodologies for fluorination and perfluoroalkylation

Authors
Adams, DJ Clark, JH Heath, PA Hansen, LB Sanders, VC Tavener, SJ
Citation
Dj. Adams et al., Novel synthetic methodologies for fluorination and perfluoroalkylation, J FLUORINE, 101(2), 2000, pp. 187-191
Citations number
10
Categorie Soggetti
Inorganic & Nuclear Chemistry
Journal title
JOURNAL OF FLUORINE CHEMISTRY
ISSN journal
00221139 → ACNP
Volume
101
Issue
2
Year of publication
2000
Pages
187 - 191
Database
ISI
SICI code
0022-1139(200002)101:2<187:NSMFFA>2.0.ZU;2-L
Abstract
Nucleophilic routes to selectively fluorinated aromatic compounds starting from cheap and readily available nitroaromatics are reviewed. Me3SiCF3, in conjunction with a fluoride, can be used as either a fluorinating or triflu oromethylating agent, and is capable of both the trifluoromethyldenitration and trifluoromethyldecyanation of an aromatic molecule. Nucleophilic trifl uoromethylthiolation can be achieved using thiophosgene and a fluoride. (C) 2000 Elsevier Science S.A. All rights reserved.