Effect of nifedipine administration (10mg) on esophageal acid exposure time

Citation
H. Ishikawa et al., Effect of nifedipine administration (10mg) on esophageal acid exposure time, J GASTRO, 35(1), 2000, pp. 43-46
Citations number
13
Categorie Soggetti
Gastroenerology and Hepatology
Journal title
JOURNAL OF GASTROENTEROLOGY
ISSN journal
09441174 → ACNP
Volume
35
Issue
1
Year of publication
2000
Pages
43 - 46
Database
ISI
SICI code
0944-1174(200001)35:1<43:EONA(O>2.0.ZU;2-L
Abstract
The effect of nifedipine administration (10 mg) on esophageal acid exposure time was investigated in 11 non-reflux esophagitis (non-RE) patients and 1 1 grade C (Los Angeles classification) reflux esophagitis (RE) patients. In each subject, esophageal pH monitoring was performed, with the subject in the supine position, preprandially (1 h) and 3-h postprandially after oral administration of a placebo in the morning and oral administration of nifed ipine (10 mg) an the afternoon on the same day. In the non-RE patients, the re was no difference in the esophageal acid exposure time between administr ation of the placebo and that of nifedipine. In patients with RE, the esoph ageal acid exposure time after the administration of nifedipine was signifi cantly (P < 0.05) longer than that after the placebo. In patients with seve re RE, the severi:ty of RE may worsen with nifedipine administration.