Psychiatric symptoms of inherited metabolic disease

Inborn errors of metabolism often present with a variety of psychiatric sym ptoms. With improved diagnosis and treatment options, many patients have in creased lifespans; consequently, issues of long-term quality of life are co ming to the forefront. Mental health concerns are among these issues. To de monstrate the connection between the course of metabolic disease and its ps ychiatric manifestations, four different inborn errors of metabolism are re viewed: phenylketonuria, Wilson disease, acute intermittent porphyria, and metachromatic leukodystrophy.