ANGINA-PECTORIS OCCURRING DURING GRANULOCYTE-COLONY-STIMULATING FACTOR-COMBINED PREPARATORY REGIMEN FOR AUTOLOGOUS PERIPHERAL-BLOOD STEM-CELL TRANSPLANTATION IN A PATIENT WITH ACUTE MYELOGENOUS LEUKEMIA

We describe a patient with acute myelogenous leukaemia who developed a ngina pectoris during pretransplant conditioning for autologous periph eral blood stem cell transplantation (PBSCT); the conditioning regimen consisted of cytotoxic drugs in combination with granulocyte colony-s timulating factor (G-CSF). Neutrophilia and hypercoagulability were ob served at the time of angina pectoris. Recurrence of angina pectoris w as not seen after nitrate and aspirin therapy. Exercise stress testing performed after PBSCT suggested the presence of myocardial ischaemia. Therefore cases at risk of vascular events should be carefully manage d with prophylactic treatment during G-CSF administration.