Domain motions in proteins

New numerical techniques permit the identification and characterization of dynamical domains in proteins with almost negligible computational effort. The validity of the approximations on which these techniques are based prov ides valuable insight into the nature of the energy landscape of proteins. An easy-to-use interactive analysis program based on the new methods is ava ilable. Extensions to higher frequency ranges are discussed briefly. (C) 20 00 Elsevier Science B.V. All rights reserved.