Three new natural products, bengamide Y (1), bengamide Z (3), and bengazole
Z (5), were isolated from the aqueous extract of an Australian collection
of the sponge Jaspis sp. Their structures were solved by spectroanalytical
methods and by comparison of their spectral data with known bengamides and
bengazoles that were reported from the same genus. Bengamides Y (1) and Z (
3) showed a striking differential cytotoxicity pattern against a panel of 1
0 human tumor cell lines, with closely related cell lines (e.g., SNB-19 and
SNB-75) displaying significant differences in sensitivity.