Anti-IL-12 antibody prevents the development and progression of multiple sclerosis-like relapsing-remitting demyelinating disease in NOD mice inducedwith myelin oligodendrocyte glycoprotein peptide

Treatment with monoclonal anti-IL-12 antibody injected on day 0, 7 and 10 a fter immunization with myelin oligodendrocyte glycoprotein (MOG) peptide 35 -55 in NOD mice resulted in significant suppression of the development and the severity of the chronic relapsing-remitting experimental autoimmune enc ephalomyelitis (EAE) both clinically and histologically. The spleen cells f rom anti-IL-12 antibody treated mice displayed markedly inhibited MOG(35-55 ) specific proliferation and IFN-gamma production. MOG(35-55) specific anti body production was enhanced by anti-IL-12 antibody treatment. These result s suggest that IL-12 is critically involved in the pathogenesis of MOG-indu ced EAE and that antibody to IL-12 could be an effective therapeutic agent in the clinical treatment of autoimmune demyelinating diseases such as mult iple sclerosis (MS). (C) 2000 Elsevier Science B.V. All rights reserved.