K. Sakamoto et al., IDENTIFICATION OF A CHICK HOMOLOG OF FRINGE AND C-FRINGE-1 - INVOLVEMENT IN THE NEUROGENESIS AND THE SOMITOGENESIS, Biochemical and biophysical research communications, 234(3), 1997, pp. 754-759
In Drosophila, Serrate plays an important role to the wing margin form
ation. A putative secretory protein, Fringe, is indispensable for the
wing margin formation inducing Serrate and other genes. Recently, Xeno
pus homologues of Fringe were identified and one of them, lunatic Frin
ge (X-1Fng), was demonstrated to be involved in mesoderm induction. We
have identified two chick Fringe homologous genes by reverse transcri
ption-polymerase chain reaction and cDNA library screening. One of the
m, C-Fringe 1, showed sequence similarity to X-1Fng. In situ hybridiza
tion study of C-Fringe 1 has demonstrated its expression in the develo
ping nervous system and in the presomitic mesoderm. The hindbrain and
spinal cord showed the distinct stripe pattern expression which was co
mplementary to that of C-Serrate, indicating the correlation between t
hem in vertebrate. (C) 1997 Academic Press.