Objective: To describe the development, use, and psychometric properties of
the semistructured, symptom-oriented Interview Schedule for Children and A
dolescents (ISCA) and its versions suitable for reevaluation. Method: Data
are summarized on the reliability, construct validity, and predictive valid
ity of symptom ratings and resultant diagnoses, and information regarding t
he feasibility of a version of the ISCA for young adult subjects is present
ed. Results: The evidence suggests that these instruments yield reliable sy
mptom ratings and diagnoses relevant to a wide range of syndromes and diagn
oses over time and that the ISCA is useful with psychiatric and pediatric m
edical populations. Conclusions: The ISCA and its follow-up versions are us
eful clinical tools in research focusing on developmental psychopathology.