A convergent approach to coenzyme Q

Authors
Lipshutz, BH Bulow, G Fernandez-Lazaro, F Kim, SK Lowe, R Mollard, P Stevens, KL
Citation
Bh. Lipshutz et al., A convergent approach to coenzyme Q, J AM CHEM S, 121(50), 1999, pp. 11664-11673
Citations number
65
Categorie Soggetti
Chemistry & Analysis",Chemistry
Journal title
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
ISSN journal
00027863 → ACNP
Volume
121
Issue
50
Year of publication
1999
Pages
11664 - 11673
Database
ISI
SICI code
0002-7863(199912)121:50<11664:ACATCQ>2.0.ZU;2-I
Abstract
Syntheses of coenzyme Q(3-8) are described, as well as related systems such as plastoquinone-5. Preparation of thr higher homologues of the ubiquinone s relies on two new conjunctive reagents, or "linchpins", each of which ult imately corresponds to two or three prenyl units. These allow for attachmen t of a polyprenyl halide at one end, followed by a Ni(0)-catalyzed cross-co upling at the other terminus with a chloromethylated p-quinone.