CYTOTOXIC DEGRADATION PRODUCT OF PHYSOSTIGMINE

Authors
POOBRASERT O CHAI H PEZZUTO JM CORDELL GA
Citation
O. Poobrasert et al., CYTOTOXIC DEGRADATION PRODUCT OF PHYSOSTIGMINE, Journal of natural products, 59(11), 1996, pp. 1087-1089
Citations number
16
Categorie Soggetti
Chemistry,"Plant Sciences","Pharmacology & Pharmacy
Journal title
Journal of natural products → ACNP
ISSN journal
01633864
Volume
59
Issue
11
Year of publication
1996
Pages
1087 - 1089
Database
ISI
SICI code
0163-3864(1996)59:11<1087:CDPOP>2.0.ZU;2-W
Abstract
Rubreserine (3), a known degradation product of physostigmine (1), and a new indole derivative, 4, were isolated when 1 was refluxed with NH 4OH. The structure of the rearrangement product of 1, compound 4, was deduced through the interpretation of NMR data. Rubreserine (3) was ve ry weakly cytotoxic to KB (human oral epidermoid carcinoma) and LNCaP (hormone-dependent human prostate cancer) cells and was active in the ASK (astrocytoma) assay. Compound 4 showed potent cytotoxicity in all cell lines tested.