Cyclic (4S)-chloromethyl sulfite and sulfate derivatives of (S)-glycidol as valuable synthetic equivalents of scalemic epichlorohydrin

Authors
Bredikhin, AA Lazarev, SN Pashagin, AV Bredikhina, ZA
Citation
Aa. Bredikhin et al., Cyclic (4S)-chloromethyl sulfite and sulfate derivatives of (S)-glycidol as valuable synthetic equivalents of scalemic epichlorohydrin, MENDELEEV C, (6), 1999, pp. 236-237
Citations number
21
Categorie Soggetti
Chemistry
Journal title
MENDELEEV COMMUNICATIONS
ISSN journal
09599436 → ACNP
Issue
6
Year of publication
1999
Pages
236 - 237
Database
ISI
SICI code
0959-9436(1999):6<236:C(SASD>2.0.ZU;2-Z
Abstract
The interaction of (S)-glycidol with SOCl2 or SO2Cl2 in stoichiometric amou nts leads to the formation of cyclic (4S)-chloromethyl sulfite or sulfate d erivatives with the same enantiomeric purity; based on this reaction, a new procedure for the synthesis of (S)-propranolol was developed.