K. Kajinami et al., Coronary ectasia in familial hypercholesterolemia: Histopathologic study regarding matrix metalloproteinases, MOD PATHOL, 12(12), 1999, pp. 1174-1180
Citations number
29
Categorie Soggetti
Research/Laboratory Medicine & Medical Tecnology","Medical Research Diagnosis & Treatment
A 39-year-old male heterozygous familial hypercholesterolemia patient with
marked ectasia over the entire coronary artery tree had been treated with s
everal kinds of lipid-lowering single or combined drug therapies using clof
ibrate, compactin, cholestyramine, probucol, and pravastatin, and LDL-apher
esis. During the 19-year follow-up, he suffered myocardial infarction three
times and some of the ectatic coronary segments became enlarged, others na
rrowed, and one of them occluded in spite of the treatment. At the age of 5
8, he died after a fourth cardiac attack and subsequent cardiogenic shock.
The autopsy indicated that his three coronary arteries showed diffuse ectat
ic changes and the largest lumen diameter of the left anterior descending a
rtery was 25 mm, of the circumflex artery 12 mm, and of the right coronary
artery 13 mm. The ectatic artery wall was not thick and the major part of t
he lumen was occupied by organized thrombi. Microscopic examinations showed
that the larger the diameter of the lumen, the more severe the structural
damage of the intima and tunica media and the larger the number of infiltra
ted cells, including lymphocytes, macrophages, and plasma cells. Immunoreac
tivity against matrix metalloproteinase (MMP)-1, and MMP-2 was observed in
smooth muscle cells, macrophages, lymphocytes, and endothelial cells of the
vasa vasorum or neovasculature. MMP-9 immunoreactivity was also localized
in intimal foamy macrophages and round cells (macrophages and lymphocytes)
of the media and adventitia. MMP-1 increased with the lumen diameter of the
ectatic arteries. The ratio of immunoreactivity against both MMP-2 and MMP
-9 to that against tissue inhibitor of metalloproteinase (TIMP)-2 also incr
eased with the lumen diameter, but it no longer increased when the diameter
was over 10 mm. These observations suggest that the MMP-TIMP system appear
s to play a significant role in the development of coronary ectasia.