CHONDROITIN ABC LYASE DIGESTION OF AN ASCIDIAN DERMATAN SULFATE - OCCURRENCE OF UNUSUAL -2-DEOXY-3-O-(2-O-SULFO-ALPHA-L-IDOPYRANOSYLURONIC ACID)-BETA-D-GALACTOSE UNITS

Authors
MOURAO PAS PAVAO MSG MULLOY B WAIT R
Citation
Pas. Mourao et al., CHONDROITIN ABC LYASE DIGESTION OF AN ASCIDIAN DERMATAN SULFATE - OCCURRENCE OF UNUSUAL -2-DEOXY-3-O-(2-O-SULFO-ALPHA-L-IDOPYRANOSYLURONIC ACID)-BETA-D-GALACTOSE UNITS, Carbohydrate research, 300(4), 1997, pp. 315-321
Citations number
17
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Carbohydrate research → ACNP
ISSN journal
00086215
Volume
300
Issue
4
Year of publication
1997
Pages
315 - 321
Database
ISI
SICI code
0008-6215(1997)300:4<315:CALDOA>2.0.ZU;2-X
Abstract
A dermatan sulfate-like glycosaminoglycan was isolated from the body o f the ascidian Ascidia nigra (J. Biol. Chem. 270: 31027-31036, 1995). H-1 NMR and fast atom bombardment mass spectrometry (FAB-MS) spectra o f the tetra and disaccharides formed by chondroitin ABC lyase digestio n support the proposed repeating disaccharide structure for this glyco saminoglycan, IdoA(2SO(4))-(1-->3)-beta-D-GalNAc(6SO(4))-(1-->], which differ from mammalian dermatan sulfate in its sulfation at both 2-pos ition of the alpha-L-iduronic acid and the 6-position of the N-acetyl- beta-D-galactosamine residue. (C) 1997 Elsevier Science Ltd.