SCLEROTIAMIDE - A NEW MEMBER OF THE PARAHERQUAMIDE CLASS WITH POTENT ANTIINSECTAN ACTIVITY FROM THE SCLEROTIA OF ASPERGILLUS-SCLEROTIORUM

Authors
WHYTE AC GLOER JB WICKLOW DT DOWD PF
Citation
Ac. Whyte et al., SCLEROTIAMIDE - A NEW MEMBER OF THE PARAHERQUAMIDE CLASS WITH POTENT ANTIINSECTAN ACTIVITY FROM THE SCLEROTIA OF ASPERGILLUS-SCLEROTIORUM, Journal of natural products, 59(11), 1996, pp. 1093-1095
Citations number
13
Categorie Soggetti
Chemistry,"Plant Sciences","Pharmacology & Pharmacy
Journal title
Journal of natural products → ACNP
ISSN journal
01633864
Volume
59
Issue
11
Year of publication
1996
Pages
1093 - 1095
Database
ISI
SICI code
0163-3864(1996)59:11<1093:S-ANMO>2.0.ZU;2-P
Abstract
Sclerotiamide (1), a new fungal natural product related to the paraher quamides, was isolated by bioassay-guided fractionation of antiinsecta n organic extracts from the sclerotia of Aspergillus sclerotiorum (NRR L 5167). The structure was determined primarily through H-1-NMR, C-13- NMR, HMQC, and HMBC experiments. Sclerotiamide causes significant mort ality and unusual physiological effects in dietary assays against the corn earworm Helicoverpa zea.