Certain 3,9-dideazapurines as inhibitors of purine nucleoside phosphorylase

Authors
Rose, JD Secrist, JA Montgomery, JA
Citation
Jd. Rose et al., Certain 3,9-dideazapurines as inhibitors of purine nucleoside phosphorylase, NUCLEOS NUC, 18(11-12), 1999, pp. 2443-2461
Citations number
28
Categorie Soggetti
Biochemistry & Biophysics
Journal title
NUCLEOSIDES & NUCLEOTIDES
ISSN journal
07328311 → ACNP
Volume
18
Issue
11-12
Year of publication
1999
Pages
2443 - 2461
Database
ISI
SICI code
0732-8311(1999)18:11-12<2443:C3AIOP>2.0.ZU;2-U
Abstract
The synthesis of four 3,9-dideazapurines is described. In order to achieve the desired substitution pattern, a new approach to the pyrrolo[2,3-c]pyrid ine ring system was devised utilizing the Gassman reaction as the key step for its construction. The four target heterocycles were all evaluated for t heir ability to inhibit human erythrocytic purine nucleoside phosphorylase.