Synthesis, cytotoxic effect and antiviral activity of 1-(beta-D-arabinofuranosyl)-5-bromo-N-4-substituted cytosine and 1-(beta-D-arabinofuranosyl)-5-bromo-4-methoxypyrimidin-2(1H)-one derivatives

Authors
Saladino, R Mezzetti, M Mincione, E Palamara, AT Savini, P Marini, S
Citation
R. Saladino et al., Synthesis, cytotoxic effect and antiviral activity of 1-(beta-D-arabinofuranosyl)-5-bromo-N-4-substituted cytosine and 1-(beta-D-arabinofuranosyl)-5-bromo-4-methoxypyrimidin-2(1H)-one derivatives, NUCLEOS NUC, 18(11-12), 1999, pp. 2499-2510
Citations number
27
Categorie Soggetti
Biochemistry & Biophysics
Journal title
NUCLEOSIDES & NUCLEOTIDES
ISSN journal
07328311 → ACNP
Volume
18
Issue
11-12
Year of publication
1999
Pages
2499 - 2510
Database
ISI
SICI code
0732-8311(1999)18:11-12<2499:SCEAAA>2.0.ZU;2-8
Abstract
A convenient and mild synthesis of 5-bromo-N-4-substituted-1-(beta-D-arabin ofuranosyl)cytosine and 5-bromo-O-4-methyl-1-(beta-D-arabinofuranosyl)pyrim idin-2(1H)-one derivatives by selective oxyfunctionalization of the corresp onding 4-thionucleosides with 3,3-dimethyldioxirane is reported. The cytoto xicity and the antiviral activity against parainfluenza 1 (Sendai virus) of all new synthesized products are also reported.