Dm. Brown et al., L-nucleoside analogues as potential antimalarials that selectively target Plasmodium falciparum adenosine deaminase, NUCLEOS NUC, 18(11-12), 1999, pp. 2521-2532
The L-stereoisomer analogues of D-coformycin selectively inhibited P. falci
parum adenosine deaminase (ADA) in the picomolar range (L-isocoformycin, K-
i 7 pM; L-coformycin, K-i 250 pM). While the L-nucleoside analogues, L-aden
osine, 2,6-diamino-9-(L-ribofuranosyl)purine and 4-amino-1-(L-ribofuranosyl
)pyrazolo [3,4-d]-pyrimidine were selectively deaminated by P. falciparum A
DA, L-thioinosine and L-thioguanosine were not. This is the first example o
f 'non-physiological' L-nucleosides that serve as either substrates or inhi
bitors of malarial ADA and are not utilised by mammalian ADA.