Polyester and N-methyl analogues of peptide nucleic acids: Synthesis and hybridization properties

Authors
Efimov, VA Buryakova, AA Choob, MV Chakhmakhcheva, OG
Citation
Va. Efimov et al., Polyester and N-methyl analogues of peptide nucleic acids: Synthesis and hybridization properties, NUCLEOS NUC, 18(11-12), 1999, pp. 2533-2549
Citations number
29
Categorie Soggetti
Biochemistry & Biophysics
Journal title
NUCLEOSIDES & NUCLEOTIDES
ISSN journal
07328311 → ACNP
Volume
18
Issue
11-12
Year of publication
1999
Pages
2533 - 2549
Database
ISI
SICI code
0732-8311(1999)18:11-12<2533:PANAOP>2.0.ZU;2-9
Abstract
The synthesis of a set of homo-thymine analogues of peptide nucleic acids c ontaining ester or N-methylamide linkages as well as analogues derived from trans-4-hydroxy-L-proline and their hybrids has been accomplished, and the ir binding affinity to complementary DNA and RNA strands was evaluated.