Straightforward synthesis of lupophilic thymidine glucopyranosyl monophosphates as models for a drug delivery system across cellular membranes

Citation
E. Belsito et al., Straightforward synthesis of lupophilic thymidine glucopyranosyl monophosphates as models for a drug delivery system across cellular membranes, NUCLEOS NUC, 18(11-12), 1999, pp. 2565-2580
Citations number
25
Categorie Soggetti
Biochemistry & Biophysics
Journal title
NUCLEOSIDES & NUCLEOTIDES
ISSN journal
07328311 → ACNP
Volume
18
Issue
11-12
Year of publication
1999
Pages
2565 - 2580
Database
ISI
SICI code
0732-8311(1999)18:11-12<2565:SSOLTG>2.0.ZU;2-3
Abstract
O-methyl (3'-6) and (5'-6) thymidinyl gluco- and mannopyranosides and (3'-6 ) thymidinyl glucofuranose can be synthesised in excellent yields by applyi ng the phosphotriester method. The lipophilic phosphotriesters thus obtaine d are designed as carriers of nucleoside drugs across cellular membranes.