Citation
J. Zachova et al., Crystal and solution structure of 5 '-O-(guanosine-2 '-O-phosphonomethyl)cytidine, an isopolar nonisosteric phosphonate analog of GpC., NUCLEOS NUC, 18(11-12), 1999, pp. 2581-2599
Citations number
46
Categorie Soggetti
Biochemistry & Biophysics
Journal title
NUCLEOSIDES & NUCLEOTIDES
ISSN journal
07328311
→ ACNP
Volume
18
Issue
11-12
Year of publication
1999
Pages
2581 - 2599
Database
ISI
SICI code
0732-8311(1999)18:11-12<2581:CASSO5>2.0.ZU;2-A
Abstract
X-Ray crystal structure of 5'-O-(guanosine-2'-O-phosphonomethyl)-cytidine (
G-p(c)C(2'-5')) was determined. The structural unit involves two molecules
cf G-p(c)C(2'-5') differing both in the conformation of the phosphonate int
ernucleotide linkage and in the intramolecular base-plane distances (3.6 An
gstrom; 3.3 Angstrom), and fourteen molecules of water. The crystal data of
G-p(c)C(2'-5') are discussed along with those. obtained from NMR spectra.