d(GCGTAGC), an equilibrium between a hairpin structure and an unusual duplex

Authors
Lescrinier, E Sheng, SQ Schraml, J Busson, R Herdewijn, P
Citation
E. Lescrinier et al., d(GCGTAGC), an equilibrium between a hairpin structure and an unusual duplex, NUCLEOS NUC, 18(11-12), 1999, pp. 2721-2744
Citations number
34
Categorie Soggetti
Biochemistry & Biophysics
Journal title
NUCLEOSIDES & NUCLEOTIDES
ISSN journal
07328311 → ACNP
Volume
18
Issue
11-12
Year of publication
1999
Pages
2721 - 2744
Database
ISI
SICI code
0732-8311(1999)18:11-12<2721:DAEBAH>2.0.ZU;2-V
Abstract
The DNA heptamer d(GCGTAGC), as determined by NMR spectroscopy, occurs in a queous solution in a temperature- and salt-dependent equilibrium between a monoloop hairpin (where the unpaired thymidine, forming the loop, is stacke d on top of the guanine (G3) base) and a duplex with the unpaired thymidine residues from opposite strands intercalating and costacking between shared G:A pairs.