GLYCOSYLATION OF 2-THIOURACIL DERIVATIVES - A SYNTHETIC APPROACH TO 3-GLYCOSYL-2,4-DIOXYPYRIMIDINES

Authors
KHODAIR AI IBRAHIM EE ELASHRY ESH
Citation
Ai. Khodair et al., GLYCOSYLATION OF 2-THIOURACIL DERIVATIVES - A SYNTHETIC APPROACH TO 3-GLYCOSYL-2,4-DIOXYPYRIMIDINES, Nucleosides & nucleotides, 16(4), 1997, pp. 433-444
Citations number
20
Categorie Soggetti
Biology
Journal title
Nucleosides & nucleotides → ACNP
ISSN journal
07328311
Volume
16
Issue
4
Year of publication
1997
Pages
433 - 444
Database
ISI
SICI code
0732-8311(1997)16:4<433:GO2D-A>2.0.ZU;2-I
Abstract
Reaction of 6-aryl-5-cyano-2-thiouracils 2a-d with glycosyl halides 4a ,b under alkaline conditions gave the respective bisglycosylated deriv atives 5a-h. However, their deacetylation with ammonia in methanol cau sed a cleavage of the S-glycosyl residue and gave the N-3 glycosylated analogues 6a-h.