The efficacy of the Shack-Hartmann technique for measuring the optical aber
rations of the eye was evaluated for four classes of clinical conditions as
sociated with optically abnormal eyes. These categories (with specific exam
ples) are: anomalies of the tear film (dry eye), corneal disease (keratocon
us), corneal refractive surgery [laser-assisted in situ keratomileusis (LAS
IK)], and lenticular cataract. We show that in each of these cases, it is p
ossible to obtain at least a partial topographic map of the refractive aber
rations of the patient's eyes, but severe losses of data integrity can occu
r. We further show that the Shack-Hartmann aberrometer provides additional
information about the eye's imperfections on a very fine spatial scale (< 0
.4 mm) which scatter light and further degrade the quality of the retinal i
mage. Taken together, spatial maps of the variation of optical aberrations
and scatter across the eye's entrance pupil represents an improved descript
ion of the optical imperfections of the abnormal eye.