In this paper, we apply the asymptotic theory of panel cointegration develo
ped by Kao and Chiang (1998) to Coe and Helpman's (1995) international R&D
spillovers regression. The OLS with bias-correction, the fully-modified (FM
) and the dynamic OLS (DOLS) estimations produce different predictions abou
t the impact of foreign R&D on total factor productivity (TFP) although all
the estimations support the result that domestic R&D is related to TFP.