DD Genotype of the angiotensin-converting enzyme gene and stroke in Slovenian population

The angiotensin-converting enzyme (ACE) is a rate-limiting enzyme in the re nin angiotensin system, the enzyme is involved in the vascular remodelling and atherosclerosis. Its significance in pathogenesis of ischemic cerebrova scular insults (CVI) is not known. We analysed 124 Slovenian patients with CVI and compared them with 161 healthy controls for I/D polymorphism. Under a recessive model (chi(2) = 1.76, p = 0.1, OR = 1.40, 95% CI: 0.85 - 2.34) we found no significant difference in VD genotypes between patients with C VI and controls. This study shows that in a group of Slovenian CVI patients the DD genotype is not an important risk factor for the development of str oke.