Effects of immobilization stress combined with water immersion and chronicamphetamine treatment on the adenylyl cyclase activity in rat neurohypophysis

Several papers have indicated the participation of cyclic AMP as a second m essenger for the release of neurohypophysial hormones. Since very little is known about the effects of stress and drugs of abuse on this process, we s tudied the activity of adenylyl cyclase in the neurohypophyses after immobi lization stress and chronic amphetamine treatment. Our findings indicate th e involvement of cyclic AMP in the regulation of neurohypophysis as well as the increase in total adenylyl cyclase both after application of immobiliz ation stress combined with water immersion and after chronic amphetamine tr eatment.