Mesoscopic organization in soft, hard, and biological matter is examined in
the context of our present understanding of the principles responsible for
emergent organized behavior (crystallinity, ferromagnetism, superconductiv
ity, etc.) at long wavelengths in very large aggregations of particles. Par
ticular attention is paid to the possibility that as-yet-undiscovered organ
izing principles might be at work at the mesoscopic scale, intermediate bet
ween atomic and macroscopic dimensions, and the implications of their disco
very for biology and the physical sciences. The search for the existence an
d universality of such rules, the proof or disproof of organizing principle
s appropriate to the mesoscopic domain, is called the middle way.