Reactive oxygen species and nitric oxide mediate plasticity of neuronal calcium signaling

Citation
O. Yermolaieva et al., Reactive oxygen species and nitric oxide mediate plasticity of neuronal calcium signaling, P NAS US, 97(1), 2000, pp. 448-453
Citations number
49
Categorie Soggetti
Multidisciplinary
Journal title
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
ISSN journal
00278424 → ACNP
Volume
97
Issue
1
Year of publication
2000
Pages
448 - 453
Database
ISI
SICI code
0027-8424(20000104)97:1<448:ROSANO>2.0.ZU;2-9
Abstract
Reactive oxygen species (ROS) and nitric oxide (NO) are important participa nts in signal transduction that could provide the cellular basis for activi ty-dependent regulation of neuronal excitability. In young rat cortical bra in slices and undifferentiated PC12 cells, paired application of depolariza tion/agonist stimulation and oxidation induces long-lasting potentiation of subsequent Ca2+ signaling that is reversed by hypoxia. This potentiation c ritically depends on NO production and involves cellular ROS utilization. T he ability to develop the Ca2+ signal potentiation is regulated by the deve lopmental stage of nerve tissue, decreasing markedly in adult rat cortical neurons and differentiated PC12 cells.