Design, syntheses and biological activity of novel ALS inhibitors (IX) - CoMFA of sulfonylureas and triazolopyrimidine-2-sulfonamides ALS inhibitors

Quantitative structure-activity relationships for herbicidal activity again st rape of sulfonylurea and triazolopyrimidine-2-sulfonamide derivatives we re examined three-dimensionally using comparative molecular field analysis (Co;MFA). The CoMFA results show that the slopes in steric and electrostati c fields around the molecule were significant for both series in governing the potency variations in herbicidal activity. Based upon the successful su perposition between the two series, the herbicidal activity was analyzable with a single equation for the combined set of compounds, which suggested t hat the two different series of compounds have a common region of the recep tor site.