D. Closa et al., XANTHINE-OXIDASE ACTIVATION IN CERULEIN-INDUCED AND TAUROCHOLATE-INDUCED ACUTE-PANCREATITIS IN RATS, ARCH I PHYS, 102(3), 1994, pp. 167-170
Citations number
25
Categorie Soggetti
Physiology,Biology,Biophysics
Journal title
Archives internationales de physiologie, de biochimie et de biophysique
Oxygen free radicals (OFR) are postulated to play a role in the pathog
enesis of acute pancreatitis. The aim of this work was to examine the
role of xanthine oxidase in the generation of OFR and the activity of
the endogenous defense mechanisms as reflected by pancreatic superoxid
e dismutase (SOD) activity in a model of edematous pancreatitis induce
d in rats by administration of cerulein at supramaximal doses, as well
as in necrohemorrhagic model induced by intraductal administration of
sodium taurocholate. Comparison between these two models of pancreati
tis suggests important differences in origin and importance in the evo
lution of injury. In necrohemorrhagic pancreatitis OFR can be produced
by xanthine oxidase activity probably associated to cell death. By co
ntrast, in cerulein induced pancreatitis, other sources of oxygen free
radicals, such as inflammatory cells, can be of more importance.