P. Massanyi et V. Uhrin, HISTOLOGICAL-CHANGES IN THE UTERUS OF RABBITS AFTER AN ADMINISTRATIONOF CADMIUM, Journal of environmental science and health. Part A: Environmental science and engineering, 32(5), 1997, pp. 1459-1466
The effects of cadmium on the uterus of rabbits were studied by light
microscopy with morphometry. The experiment involved 32 animals. Cadmi
um was applied intraperitoneally (i.p.) to group A (1.5 mg/kg body wei
ght), perorally (p.o.) to group B (1.0 mg/kg b.w.) for a 5-month perio
d, and also p.o. (1.0 mg/kg b.w.) for a 5-month period of application
followed by a 7-month cessation of application for group C. All experi
mental groups were compared to a control group (K), as well as to othe
r experimental groups. Animals were examined after the experimental pe
riod. In the uterus, the amount of endometrium was in the range of 48.
42% to 50.37%, and that of myometrium of 51.58% to 49.63%. The percent
age of glandular epithelium in the endometrium was significantly lower
in group A in comparison with group C (P<0.05). Amount of stroma was
significantly higher in the group receiving i.p., in comparison with t
he group receiving p.o. administration for a 5-month period (p<0.01).
From the photographed pictures edematization of uterus with desintegra
tions in the blood vessel wall and subsequent diapedesis were evident.