Thiol addition to aryl propargyl alcohols under mild conditions: an accelerating neighboring group effect

Authors
Waters, MS Cowen, JA McWilliams, JC Maligres, PE Askin, D
Citation
Ms. Waters et al., Thiol addition to aryl propargyl alcohols under mild conditions: an accelerating neighboring group effect, TETRAHEDR L, 41(2), 2000, pp. 141-144
Citations number
22
Categorie Soggetti
Chemistry & Analysis","Organic Chemistry/Polymer Science
Journal title
TETRAHEDRON LETTERS
ISSN journal
00404039 → ACNP
Volume
41
Issue
2
Year of publication
2000
Pages
141 - 144
Database
ISI
SICI code
0040-4039(20000108)41:2<141:TATAPA>2.0.ZU;2-M
Abstract
Aryl alkynols provide a convenient entry into alpha-hydroxyketones via thio l addition followed by hydrolysis. Thiols have been added to several non-ac tivated alkynes under mild, basic conditions. A coordinating functional gro up in close proximity to the triple bond facilitates this reaction. (C) 199 9 Elsevier Science Ltd. All rights reserved.