Rg. Frykberg et al., DIFFERENCE IN TREATMENT OF FOOT ULCERATIONS IN BOSTON, USA AND PISA, ITALY, Diabetes research and clinical practice, 35(1), 1997, pp. 21-26
Primary care of the diabetic patient with foot ulcer can be provided b
y medically or surgically trained practitioners. We have prospectively
followed 90 sequential patients with newly developed foot ulcers from
two major centers, one in the USA where the primary doctor was a podi
atrist and one in Europe with a diabetologist. Thirty-four patients fr
om Boston and 56 from Pisa (mean age, 55.6; range, 26-75 years; vs. 66
.5; range, 35-94; P < 0.001), matched for sex, weight, type, duration
of diabetes, renal impairment and retinopathy took part. Boston patien
ts had more severe neuropathy, assessed with clinical examination util
izing a neuropathy disability score (NDS) (16 +/- 6 vs. 6 +/- 3 (mean
+/- S.D.) P < 0.001) and vibration perception threshold (46 +/- 8 vs.
35 +/- 12 V; P < 0.001) while no difference existed in the number of p
atients with clinical infection, a history of lower extremity by-pass
operation (6 (18%) vs. 3 (5%); P = NS) and in the size and the severit
y of the ulcer, according to the Wagner classification. Initial treatm
ent was similar in both centers with emphasis on outpatient ulcer debr
idement, pressure relieving foot-wear and topical wound care. Hospital
ization was needed in five (15%) Boston and 12 (21%) Pisa patients (P
= NS) while surgery was performed on five (15%) Boston and 16 (29%) Pi
sa patients (P = NS). The in-hospital stay was similar in both centers
(1.4 +/- 4.4 vs. 2.1 +/- 5.9 days; P = NS). The most common operation
s in both centers were incision, drainage and bone debridement. Ulcers
healed in all patients but the amount of healing time was shorter in
Boston patients (6.7 +/- 4.2 vs. 10.5 +/- 6.5 weeks; P < 0.02). We con
clude that despite the differences in the two systems similar success
rates were achieved in the two centers while a more surgically oriente
d strategy may have resulted in a slightly shorter healing time. (C) 1
997 Elsevier Science Ireland Ltd.