Sk. Dunyo et al., A study on the provocative day test effect of ivermectin and albendazole on nocturnal periodic Wuchereria bancrofti microfilaraemia, T RS TROP M, 93(6), 1999, pp. 608-610
Citations number
17
Categorie Soggetti
Medical Research General Topics
Journal title
TRANSACTIONS OF THE ROYAL SOCIETY OF TROPICAL MEDICINE AND HYGIENE
We conducted a randomized double-blind placebo-controlled study, in the Aha
nta West District of Ghana, on the provocative day test effect of ivermecti
n and albendazole alone and in combination on nocturnal periodic Wuchereria
bancrofti microfilaraemia. Sixty-three individuals with high night-time mi
crofilaria (mf) intensities were identified in 1997 or 1998 and randomized
into 4 groups. Blood samples for mf were then collected from the same indiv
iduals in the daytime (between 09:00 and 15:00) immediately before and 30-5
0 min after treatment. Groups 1-4 were treated with ivermectin alone (150-2
00 mu g/kg), albendazole alone (400 mg), the combination of ivermectin and
albendazole, and placebo, respectively Intensities of mf in daytime samples
were considerably lower than in night-time samples. Neither ivermectin or
albendazole alone nor their combination provoked significant liberation of
W. bancrofti mf into the peripheral circulation after the daytime treatment
.