Alternatives to bodyweight for estimating the dose of praziquantel needed to treat schistosomiasis

Citation
A. Hall et al., Alternatives to bodyweight for estimating the dose of praziquantel needed to treat schistosomiasis, T RS TROP M, 93(6), 1999, pp. 653-658
Citations number
11
Categorie Soggetti
Medical Research General Topics
Journal title
TRANSACTIONS OF THE ROYAL SOCIETY OF TROPICAL MEDICINE AND HYGIENE
ISSN journal
00359203 → ACNP
Volume
93
Issue
6
Year of publication
1999
Pages
653 - 658
Database
ISI
SICI code
0035-9203(199911/12)93:6<653:ATBFET>2.0.ZU;2-R
Abstract
Data on age, height and mid upper-arm circumference (MUAC) from nearly 6000 schoolchildren in Ghana, Tanzania and Malawi (not MUAC) were used to exami ne their power to predict bodyweight and thus the dosage of praziquantel re quired to treat schistosomiasis. Height was found to provide a simple and r easonably accurate estimate of weight, and about 75% of children would have been given a dosage of praziquantel within the range normally given using bodyweight at a dosage of 40 mg/kg bodyweight. The upper and lower ranges i n dosage did not exceed dosages of praziquantel which have been used before or are currently recommended to treat schistosomiasis. A pole marked with the number of tablets could thus be used as a simple way to determine the d ose of praziquantel to treat children in school-based health programmes.