I. Gachard et al., SYNTHESIS AND CHARACTERIZATION OF POLYAMIDES BASED ON NATURAL MONOMERS - L-LYSINE AND L-ASPARTIC ACID, Polymer bulletin, 38(6), 1997, pp. 643-649
Nonpeptidic diamine-diacid type polyamides were prepared from natural
alpha-amino acids, L-lysine and L-aspartic acid, under mild conditions
. L-lysine carboxylic group was protected as a benzyl ester; L-asparti
c acid amino group was protected as benzyloxycarbonyl (Z) or t-butylox
ycarbonyl (BOG) derivatives. The activated ester method provided polya
mides with protected amino and carboxyl side groups. The deprotection
of these side groups revealed to be perfectly selective when the amino
groups were protected as t-butyloxycarbonyl derivatives.