Matrix metalloproteinases in repair

During repair, many different matrix metalloproteinases are produced by mul tiple cell types residing in various compartments within the wound environm ent. This diversity of enzymes, coupled with discreet cellular expression, implies that different matrix metalloproteinases serve different functions, acting on a variety of substrates, during wound healing. With few exceptio ns, however, the actual function and spectrum of functions of matrix metall oproteinases in vivo is not known. Even with the advent of genetically defi ned animal models, few studies have rigorously addressed the substrates and role of matrix metalloproteinases in wound repair. Before we can understan d the role of matrix metalloproteinases in ulceration and disease, we need to determine the function these enzymes serve in normal tissues and repair.