MAJOR HISTOCOMPATIBILITY COMPLEX GENES IN A MEXICAN FAMILY WITH DEFICIENCY OF THE 2ND COMPONENT OF THE COMPLEMENT-SYSTEM

Citation
H. Melinaldana et al., MAJOR HISTOCOMPATIBILITY COMPLEX GENES IN A MEXICAN FAMILY WITH DEFICIENCY OF THE 2ND COMPONENT OF THE COMPLEMENT-SYSTEM, Revista de Investigacion Clinica, 48(4), 1996, pp. 307-309
Citations number
13
Categorie Soggetti
Medicine, General & Internal
ISSN journal
00348376
Volume
48
Issue
4
Year of publication
1996
Pages
307 - 309
Database
ISI
SICI code
0034-8376(1996)48:4<307:MHCGIA>2.0.ZU;2-M
Abstract
Hereditary deficiency of the second component of the complement system is an uncommon condition that has been reported so far mostly in Cauc asians. We describe a Mexican patient with undetectable C2 levels and absence of complement hemolytic activity. Major histocompatibility com plex (MHC) genes in his family showed that the proband had the MHC hap lotypes HLA-A25, B18, DR2, DQ1, SQ042/HLA-A24, B18, DR2, DQ1, SQ042. A strong genetic linkage of the deficiency of the second component of t he complement gene and the HLA antigens A25, B18, and DR2, is well est ablished in Caucasian populations. This suggests that the probable ori gin of the deficiency in our patient was admixture with Caucasian ance stors.