COMPATIBILITY OF PROPOFOL INJECTABLE EMULSION WITH SELECTED DRUGS DURING SIMULATED Y-SITE ADMINISTRATION

The compatibility of a new formulation of injectable propofol with sel ected other drugs during simulated Y-site injection was studied. Two m illiliters of undiluted propofol injectable emulsion was combined with 2 mL of each of 112 other drugs in 5% dextrose injection or 0.9% sodi um chloride injection. The liquids were diluted with 6 mL of particle- free high-performance liquid chromatography (HPLC)-grade water and cen trifuged for 20 minutes. A pipette connected to a vacuum line was used to remove the fat layer at the top and most of the aqueous phase. The remaining liquid was diluted with 9 mt of particle-free HPLC-grade wa ter to facilitate visualization of any precipitate. The liquids were e xamined with the unaided eye in fluorescent light and with a Tyndall b eam to enhance visualization of small particles. Samples were evaluate d during the first 15 minutes and one hour after mixing. Propofol inje ctable emulsion was compatible with 98 of the 112 drugs tested. Fourte en drugs demonstrated incompatibilities, including precipitation, gel formation, and oiling out of cracked emulsions. During simulated Y-sit e injection, propofol injectable emulsion was compatible with most oth er drugs tested for one hour at similar to 23 degrees C.